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Active Ingredient: Orlistat

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The main reason for this is that with food, the body receives more calories than it consumes, that is, a person eats more than he needs. An important source of calories in food is fat, since burning 1 g of fat releases 2 times more energy than burning 1 g of protein or carbohydrates.

Fats contained in food are absorbed by the body only after they are broken down in the intestine by a special enzyme of the pancreas — lipase. Lipase enters the intestine at the beginning of a meal and acts so effectively that all the fats received from food are usually absorbed by 100%. Therefore, as a solution to the problem of reducing excess body weight, the scientists of the company " F. Hoffmann-La Roche " chose the neutralization of lipase.


The fundamental difference between this drug and food additives is that XENICAL is not a mixture of various substances, the mechanism of action of which is unknown, but a drug containing one known active substance orlistat with a fundamentally new, well-studied mechanism of action.

Most dietary supplements have only a temporary effect of reducing body weight, either by affecting the hunger center in the brain, or by increasing heat transfer, or by diuretic or laxative action. Therefore, after stopping taking dietary supplements, body weight increases rapidly, reaching the previous indicators.


1. After starting Xenical, some patients consume more carbohydrates and proteins, resulting in a significant increase in the caloric content of food. At the same time, they believe that "with Xenical, you can eat everything and in unlimited quantities." This is a misconception that can "negate" all the efforts of the patient. Xenical suppresses the absorption of fat, but does not affect the metabolism of proteins and carbohydrates. Unfortunately, the "ideal drug" for weight loss has not yet been created, taking which the patient could not limit himself in food.

2. As practice has shown, some patients who started taking Xenical stop taking the drug after 2-3 weeks. In most cases, this is due to the fact that people expect to get results quickly. Unfortunately, rapid weight loss without harm to health is simply impossible — what has accumulated over the years can not disappear in a week. The decrease in body weight when taking Xenical occurs gradually (on average by 1.5-4 kg per month).

3. When taking Xenical, non-split fat molecules remain in the lumen of the small intestine and mix with the feces. An increase in the fat content in the feces can be accompanied by such phenomena as the discharge of gases, increased defecation, and the stool becomes "greasy". These reactions are not caused by the Xenical itself, but by fats that are not absorbed in the intestine. These phenomena occur when the amount of fat in the diet is limited.

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Myth # 1: A person is powerless against the "fullness gene"
A genetic predisposition to fatness exists, but this does not mean that its owner is doomed to suffer from excess weight for life. According to some estimates, 82% of the world's inhabitants are genetically prone to weight gain, but not every one of these people is overweight.
In any case, the presence of the "obesity gene" in humans can only be confirmed through research. And the fact that this person has a lot of fat people in his family does not mean that he has serious problems at the genetic level.
In most cases of such "hereditary fullness", it is not so much the genes that are to blame, as the eating habits adopted in the family: overeating, love of fat and sweet, forced feeding of children, etc.If these habits are corrected, the weight will decrease, despite the "heavy heredity".

Xenical: composition, indications, dosage, side effects

The first drug for weight loss with a studied effect. Xenical (Orlistat) inhibits the absorption of up to 30% of the fat that comes with food.

Due to the reduction of their intake from the outside, the body begins to spend its own "energy resources".

Judging by the results of the intention of fat in the stool, the effect of orlistat begins after a day or two after taking it.

After the withdrawal of the drug, the degree of fat in the callus will return to the level it was before the start of taking the product.

The drug belongs to the group of hypolipidemic agents. It has an inhibitory effect on the lipases of the gastrointestinal tract. It is used to combat obesity or excess weight. The effect of the drug is due to its ability to interact with fat cells, leading to their deactivation. It counteracts the breakdown of food lipases, which blunts their absorption from the gastrointestinal tract, blocks the penetration of triglycerides into the blood.

The drug by its action provokes a lack of energy, triggering the mechanism of consumption of spare fat cells in the body. As a result, with systematic use, the drug effectively helps to reduce weight, but subject to the appropriate diet in the complex. The drug has a positive effect on the level of cholesterol and insulin, lowering them, prevents the accumulation of fat in the abdominal area.

The drug practically does not interact with the plasma when used. Dissolution occurs in the intestine, forming metabolites that are pharmacologically inactive. The drug is almost completely excreted through the intestine. Complete elimination occurs within 5 hours.

Composition and form of release

The main active substance is orlistat and an additional substance is talc.

The medical preparation is made in opaque solid gelatin capsules of turquoise color.

In the middle of the capsules, the substance is white.

The drug is produced in the form of capsules of 21 pieces per plate. The package contains 1,2 or 4 plates.

Ingredients: 1 capsule contains orlistat 120 mg.

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Myth # 2: Low-fat foods help you lose weight
Of course, excessive fat in food is harmful (especially for trans fats), but eating low-fat foods can also harm your health.
First, the body needs fat for a number of biochemical processes, such as the production of stress-resisting hormones, as well as for the absorption of calcium and fat-soluble vitamins A, D, and E.
Secondly, low-fat products themselves are devoid of normal taste, which is compensated by all kinds of food additives and sugar. Therefore, a person who is convinced that he eats correctly may not notice how many sweets he actually consumes.

Indications for the use of Xenical (Orlistat)

The drug is prescribed for long-term follow-up of patients with obesity or people with excess body weight, including those with obesity-related threats to general health and body condition. Combine with a moderate hypocaloric diet.

It is also prescribed to people with the disease type 2 diabetes mellitus with obesity in complex therapy with sugar-lowering drugs.

The drug is prescribed for obesity, the need to reduce or stabilize body weight. Also, the use of the drug is recommended for diabetes mellitus, a violation of lipid metabolism, which leads to a compaction of the walls of blood vessels and an increase in the level of cholesterol in the blood.

Orlistat is used to treat obesity. To increase the effectiveness of the use of the drug, as well as a more successful correction of body weight, the use of the drug is carried out together with the observance of a hypocaloric diet.

The drug is used to reduce the likelihood of repeated weight gain after its initial reduction. Orlistat is prescribed to obese individuals with a body mass index of more than 30 kg per m2 of body area or more than 27 kg per m2 of body area, as well as in the presence of certain other risk factors, such as diabetes mellitus, dyslipidemia or hypertension.

Contraindications to the use of Xenical

Xenical is prohibited for people with chronic malabsorption syndrome, cholestasis, excessive susceptibility to the product or various other components located in the repair shell. It is prohibited for children under the age of 12.

The use of the drug is contraindicated in the presence of cholestasis (accumulation of bile in the liver tissues), in the syndrome of insufficient absorption, as well as in the presence of increased sensitivity to the components of the drug.

Chronic malabsorption syndrome, cholestasis, hypersensitivity to Orlistat and children under 18 years of age.

It is not recommended to combine the use of Orlistat with indirect anticoagulants and cyclosporine.

Pregnancy and breast-feeding are considered relative contraindications to the appointment of Orlistat.

Before prescribing the drug, it is necessary to exclude the presence of an organic cause of obesity in the patient.

Due to the lack of reliable data on the safety of using the drug in pregnant women, as well as during lactation, the use of "Xenical" by such patients is not recommended.

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Myth # 3: Everyone who wants to lose weight needs a detox
In fact, the very real medical term "detox" has nothing to do with a marketing strategy with a similar name. This detox is performed in medical institutions in case of a threat to the patient's life, such as poisoning or an overdose of alcohol or drugs.
In other cases, in the absence of serious diseases, our body perfectly cleanses itself: the kidneys remove harmful substances from the urine, and the liver gets rid of toxins. So the best detox for our body is not a pseudo-scientific cleansing program, but a healthy diet and limiting alcohol consumption.
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Myth # 4: You can "speed up" your metabolism by eating special foods
The opinion that the metabolism can be accelerated by eating some miracle foods, such as goji berries, has not been scientifically confirmed. However, the metabolism of a person in a calm state (basal metabolism) may slightly increase after drinking tea, coffee or hot spices. But this effect is so short-lived that it does not play any role in losing weight.
But there is a method that actually speeds up the metabolism in a calm state: increasing muscle mass. In other words, the more muscles you have, the more energy your body spends, even when you do not exercise, but just relax while sitting in a chair.

Method of application

The average dose of the drug is 120 mg (which is equal to 1 capsule) three times a day with each main meal. It is possible to receive during the meal or no later than an hour from the moment of eating). If you skip a meal or if the dishes do not include fat, then you can skip the use of Xenical.

Increasing the doses above the recommended norm (three times one capsule) will not increase the effect and will not make the body lose weight faster.

Clinical studies have not found the effectiveness or harmlessness of Xenical in persons under 18 years of age.

Orlistat capsules are taken orally, during a meal (diet) or after, but not later than 60 minutes. Usually, 1 capsule (120 mg) is prescribed 3 times a day. The consequences and specifics of the use of the drug in patients with impaired liver and kidney function, as well as in children, are not known.


Cases of drug overdose are not known. If the recommended doses are overstated, side effects may increase. In particular, there are known cases of using the drug in an amount of 240 mg 3 times a day, without subsequently showing adverse events.

In clinical trials, in people with normal body weight, that obese patients, exceeding the regulated dose of the drug by 7 or more times did not affect the overall well-being. Frequent administration of a double dose of the drug three times a day for two weeks was also not accompanied by the appearance of significant malignant phenomena.

In addition, in obese patients, patients with overweight, the experience of using orlistat in a double dose three times a day for six months was not accompanied by a genuine increase in the frequency of pernicious effects.

In cases of Xenical overdose, either no side effects were reported, or no adverse reactions were distinguished from those observed when using the drug in therapeutic portions.

Side effects

When taking capsules with the drug, the following painful conditions may develop:

  • Discharge from the rectum;
  • Diarrhea;
  • Increased urge to defecate;
  • Release of gases;
  • Fecal incontinence;
  • Abdominal pain;
  • Discomfort in the gastrointestinal tract.

To minimize adverse reactions, it is necessary to remember the importance of taking dietary food during the use of the drug.

These undesirable effects are less common:

  • Deterioration of the gums and teeth;
  • Pain in the colon;
  • Skin rashes;
  • Itching;
  • The appearance of puffiness;
  • Anaphylactic shock;
  • Respiratory tract infections, ARVI, influenza;
  • Urogenital tract infections;
  • Headaches;
  • Weakness;
  • Alarm;
  • Worry.

The most common complaints during the course of treatment with Xenical concerned the gastrointestinal tract and associated peristaltic disorders.

In particular, patients were concerned about flatulence, fecal incontinence, frequent urge to empty the intestines, oily discharge.

In the area of the stomach, there was heaviness and abdominal pain, discomfort.

In women, there were also violations of the menstrual cycle, headaches.

Patients with diabetes mellitus, donating blood for analysis, received the result-a decrease in the degree of glucose in the blood.

Storage conditions

The product should be stored in a water-resistant place out of reach of the child.

Store at room temperature, but not more than 25°C. The expiration date is 3 years.

Do not use an expired medical product after the expiration of the specified storage period.